Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto H
PROVIDER: S-EPMC2881878 | biostudies-other | 2010 May
REPOSITORIES: biostudies-other
BMC gastroenterology 20100511
<h4>Background</h4>Gene transfer to the gastrointestinal (GI) mucosa is a therapeutic strategy which could prove particularly advantageous for treatment of various hereditary and acquired intestinal disorders, including inflammatory bowel disease (IBD), GI infections, and cancer.<h4>Methods</h4>We evaluated vesicular stomatitis virus glycoprotein envelope (VSV-G)-pseudotyped lentiviral vectors (LV) for efficacy of gene transfer to both murine rectosigmoid colon in vivo and human colon explants e ...[more]