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Regulation and function of innate and adaptive interleukin-17-producing cells.

ABSTRACT: Interleukin-17 (IL-17)-mediated immune responses play a crucial role in the mucosal host defence against microbial and fungal pathogens. However, the chronic activation of IL-17-producing T helper cells can cause autoimmune disease. In addition, recent studies have highlighted key roles of innate cell-mediated IL-17 responses in various inflammatory settings. Besides inflammation, there have also been intriguing findings regarding the involvement of IL-17 responses in the pathogenesis of cardiovascular diseases and tumour formation. Here, we discuss the latest discoveries in regulation and function of innate and adaptive IL-17-producing cells.

SUBMITTER: Hirota K

PROVIDER: S-EPMC3271338 | biostudies-other | 2012 Feb

REPOSITORIES: biostudies-other

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