Epithelial self-defense against cancer.

ABSTRACT: It is not clearly understood what happens at the interface between normal and transformed epithelial cells at the first step of carcinogenesis. A recent study reveals that the organized epithelial structure suppresses clonal expansion of transformed cells. Translocation from the epithelium or perturbation of intercellular adhesions may be required for transformed cells to evade the suppressive environments.

SUBMITTER: Yamauchi H 

PROVIDER: S-EPMC3494394 | biostudies-other | 2012 Nov

REPOSITORIES: biostudies-other