New sinularianin sesquiterpenes from soft coral Sinularia sp.

ABSTRACT: Four new sesquiterpenes, sinularianins C-F (3-6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1-6 were evaluated for inhibition of NF-?B activation using the cell-based HEK293 NF-?B luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.

SUBMITTER: Yang B 

PROVIDER: S-EPMC3877883 | biostudies-other | 2013 Dec

REPOSITORIES: biostudies-other