Ontology highlight
ABSTRACT:
SUBMITTER: Choo KB
PROVIDER: S-EPMC4195866 | biostudies-other | 2014 Oct
REPOSITORIES: biostudies-other
Journal of biomedical science 20141005
<h4>Background</h4>Two mature miRNA species may be generated from the 5' and 3' arms of a pre-miRNA precursor. In most cases, only one species remains while the complementary species is degraded. However, co-existence of miRNA-5p and -3p species is increasingly being reported. In this work, we aimed to systematically investigate co-expression of miRNA-5p/3p in colon cancer cells in a genome-wide analysis, and to examine cross-targeting of the dysregulated miRNAs and 5p/3p species.<h4>Results</h4 ...[more]