Ontology highlight
ABSTRACT:
SUBMITTER: Na BR
PROVIDER: S-EPMC4395477 | biostudies-other | 2015 Apr
REPOSITORIES: biostudies-other
The Journal of cell biology 20150401 1
The formation of an immunological synapse (IS) requires tight regulation of actin dynamics by many actin polymerizing/depolymerizing proteins. However, the significance of actin stabilization at the IS remains largely unknown. In this paper, we identify a novel function of TAGLN2--an actin-binding protein predominantly expressed in T cells--in stabilizing cortical F-actin, thereby maintaining F-actin contents at the IS and acquiring LFA-1 (leukocyte function-associated antigen-1) activation afte ...[more]