Ontology highlight
ABSTRACT:
SUBMITTER: Maxson JE
PROVIDER: S-EPMC4453002 | biostudies-other | 2015 Jun
REPOSITORIES: biostudies-other
Cancer research 20150601 11
Genome sequencing is revealing a vast mutational landscape in leukemia, offering new opportunities for treatment with targeted therapy. Here, we identify two patients with acute myelogenous leukemia and B-cell acute lymphoblastic leukemia whose tumors harbor point mutations in the ALK kinase. The mutations reside in the extracellular domain of ALK and are potently transforming in cytokine-independent cellular assays and primary mouse bone marrow colony formation studies. Strikingly, both mutatio ...[more]