Ontology highlight
ABSTRACT:
SUBMITTER: Ngo TT
PROVIDER: S-EPMC4770088 | biostudies-other | 2016 Feb
REPOSITORIES: biostudies-other
Nature communications 20160224
Cytosine can undergo modifications, forming 5-methylcytosine (5-mC) and its oxidized products 5-hydroxymethylcytosine (5-hmC), 5-formylcytosine (5-fC) and 5-carboxylcytosine (5-caC). Despite their importance as epigenetic markers and as central players in cellular processes, it is not well understood how these modifications influence physical properties of DNA and chromatin. Here we report a comprehensive survey of the effect of cytosine modifications on DNA flexibility. We find that even a sing ...[more]