Ontology highlight
ABSTRACT:
SUBMITTER: Duffin R
PROVIDER: S-EPMC4841390 | biostudies-other | 2016 Mar
REPOSITORIES: biostudies-other
Science (New York, N.Y.) 20160301 6279
Systemic inflammation, which results from the massive release of proinflammatory molecules into the circulatory system, is a major risk factor for severe illness, but the precise mechanisms underlying its control are not fully understood. We observed that prostaglandin E2 (PGE2), through its receptor EP4, is down-regulated in human systemic inflammatory disease. Mice with reduced PGE2 synthesis develop systemic inflammation, associated with translocation of gut bacteria, which can be prevented b ...[more]