Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC5233410 | biostudies-other | 2017 Jan
REPOSITORIES: biostudies-other
Yang Yan Y Li Ziyi Z Wu Xupeng X Chen Haolin H Xu Wenting W Xiang Qi Q Zhang Qihao Q Chen Jie J Ge Ren-Shan RS Su Zhijian Z Huang Yadong Y
Stem cell reports 20161222 1
Leydig cells (LCs) play crucial roles in producing testosterone, and their dysfunction leads to male hypogonadism. LC transplantation is a promising alternative therapy for male hypogonadism. However, the source of LCs limits this strategy for clinical applications. Here, we report our success in reprogramming mice fibroblasts into LCs by expressing three transcriptional factors, Dmrt1, Gata4, and Nr5a1. The induced Leydig-like cells (iLCs) expressed steroidogenic genes, had a global gene expres ...[more]