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Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.

ABSTRACT: NF-kappa B and H2TF1 are transcription factors that bind to related DNA sequence motifs. NF-kappa B is a constitutive factor in mature B lymphocytes and is inducible in immature B cells and nonlymphoid cells. H2TF1 is a constitutive ubiquitous transcription factor that activates expression of major histocompatibility complex class I genes. We report here the isolation of two zinc finger genes. One, named MBP-2 (major histocompatibility complex-binding protein 2), encodes a factor that has DNA-binding properties similar, if not identical, to the H2TF1 transcription factor. The second, named KBP-1 (kappa-enhancer binding protein 1), encodes a factor that is similar to, but distinct from, NF-kappa B in its DNA-binding properties and methylation interference pattern, suggesting that at least two proteins can bind to the immunoglobulin kappa gene enhancer.

SUBMITTER: Rustgi AK

PROVIDER: S-EPMC55028 | biostudies-other | 1990 Nov

REPOSITORIES: biostudies-other

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Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties.

Rustgi A K AK Van 't Veer L J LJ Bernards R R

Proceedings of the National Academy of Sciences of the United States of America 19901101 22

NF-kappa B and H2TF1 are transcription factors that bind to related DNA sequence motifs. NF-kappa B is a constitutive factor in mature B lymphocytes and is inducible in immature B cells and nonlymphoid cells. H2TF1 is a constitutive ubiquitous transcription factor that activates expression of major histocompatibility complex class I genes. We report here the isolation of two zinc finger genes. One, named MBP-2 (major histocompatibility complex-binding protein 2), encodes a factor that has DNA-bi ...[more]

PMID: 2247438

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