Ontology highlight
ABSTRACT:
SUBMITTER: Miloushev VZ
PROVIDER: S-EPMC6050093 | biostudies-other | 2018 Jul
REPOSITORIES: biostudies-other
Cancer research 20180516 14
Hyperpolarized (HP) MRI using [1-13C] pyruvate is a novel method that can characterize energy metabolism in the human brain and brain tumors. Here, we present the first dynamically acquired human brain HP 13C metabolic spectra and spatial metabolite maps in cases of both untreated and recurrent tumors. <i>In vivo</i> production of HP lactate from HP pyruvate by tumors was indicative of altered cancer metabolism, whereas production of HP lactate in the entire brain was likely due to baseline meta ...[more]