Unknown

Dataset Information

0

Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.


ABSTRACT: Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and hyperemesis with an increased risk, but the evidence remains unclear. We used data from the Generations Study, a large prospective study of women in the United Kingdom, to estimate relative risks of breast cancer in relation to a history of preeclampsia and hyperemesis using Cox regression adjusting for known breast cancer risk factors. During 7.5 years average follow-up of 82,053 parous women, 1,969 were diagnosed with invasive or in situ breast cancer. Women who had experienced preeclampsia during pregnancy had a significantly decreased risk of premenopausal breast cancer (hazard ratio (HR) =0.67, 95% confidence interval (CI): 0.49-0.90) and of HER2-enriched tumours (HR = 0.33, 95% CI: 0.12-0.91), but there was no association with overall (HR = 0.90, 95% CI: 0.80-1.02) or postmenopausal (HR = 0.97, 95% CI: 0.85-1.12) breast cancer risk. Risk reductions among premenopausal women were strongest within 20 years since the last pregnancy with preeclampsia. Hyperemesis was associated with a significantly increased risk of HER2-enriched tumours (HR = 1.76, 95% CI: 1.07-2.87), but not with other intrinsic subtypes or breast cancer risk overall. These results provide evidence that preeclampsia is associated with a decreased risk of premenopausal and HER2-enriched breast cancer and that hyperemesis, although not associated with breast cancer risk overall, may be associated with raised risk of HER2-enriched tumours.

SUBMITTER: Wright LB 

PROVIDER: S-EPMC6055869 | biostudies-other | 2018 Aug

REPOSITORIES: biostudies-other

altmetric image

Publications

Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.

Wright Lauren B LB   Schoemaker Minouk J MJ   Jones Michael E ME   Ashworth Alan A   Swerdlow Anthony J AJ  

International journal of cancer 20180323 4


Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and hyperemesis with an increased risk, but the evidence remains unclear. We used data from the Generations Study, a large prospective study of women in the United Kingdom, to estimate relative risks of breast cancer in relation to a history of preeclampsia and hyperemesis using Co  ...[more]

Similar Datasets

| S-EPMC5830585 | biostudies-literature
| S-EPMC3978643 | biostudies-literature
| S-EPMC5574033 | biostudies-literature
| S-EPMC2409691 | biostudies-other
| S-EPMC6738051 | biostudies-literature
| S-EPMC4296198 | biostudies-literature
| S-EPMC3387322 | biostudies-literature
| S-EPMC9366567 | biostudies-literature
| S-EPMC7063440 | biostudies-literature
| S-EPMC8505411 | biostudies-literature