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New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb.


ABSTRACT: A new phenylpropanoid glycoside (1), and two new coumarin glycosides (2, 3), together with two known compounds (4, 5), have been isolated from the stems of Hydrangea paniculata Sieb. Their structures have been determined by spectroscopic and chemical methods. Furthermore, compound 1 (50 ?M) exhibited significant hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage in vitro assays.

SUBMITTER: Ma J 

PROVIDER: S-EPMC6155810 | biostudies-other | 2017 Jan

REPOSITORIES: biostudies-other

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New Phenylpropanoid and Coumarin Glycosides from the Stems of Hydrangea paniculata Sieb.

Ma Jie J   Li Chuang-Jun CJ   Yang Jing-Zhi JZ   Sun Hua H   Zhang Dong-Ming DM  

Molecules (Basel, Switzerland) 20170118 1


A new phenylpropanoid glycoside (<b>1</b>), and two new coumarin glycosides (<b>2</b>, <b>3</b>), together with two known compounds (<b>4</b>, <b>5</b>), have been isolated from the stems of <i>Hydrangea paniculata</i> Sieb. Their structures have been determined by spectroscopic and chemical methods. Furthermore, compound <b>1</b> (50 μM) exhibited significant hepatoprotective activity against <i>N</i>-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage <i>in vitro</i> assays. ...[more]

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