Ontology highlight
ABSTRACT:
SUBMITTER: Huang K
PROVIDER: S-EPMC6220315 | biostudies-other | 2018 Nov
REPOSITORIES: biostudies-other
Nature communications 20181107 1
Human pluripotent stem cells (hPSCs) exhibit very limited contribution to interspecies chimeras. One explanation is that the conventional hPSCs are in a primed state and so unable to form chimeras in pre-implantation embryos. Here, we show that the conventional hPSCs undergo rapid apoptosis when injected into mouse pre-implantation embryos. While, forced-expression of BMI1, a polycomb factor in hPSCs overcomes the apoptosis and enables hPSCs to integrate into mouse pre-implantation embryos and ...[more]