Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds

ABSTRACT: Endothelial cells line blood and lymphatic vessels and form intercellular junctions, which preserve vessel structure and integrity. The vascular endothelial cadherin, VE-cadherin, mediates endothelial adhesion and is indispensible for blood vessel development and permeability regulation. However, its requirement for lymphatic vessels has not been addressed. During development, VE-cadherin deletion in lymphatic endothelial cells in mice resulted in abortive lymphangiogenesis, edema and prenatal death. Unexpectedly, inducible postnatal or adult deletion elicited vessel bed-specific responses. Mature dermal lymph vessels resisted VE-cadherin loss and maintained button junctions, which was associated with an upregulation of junctional molecules. On the contrary, mesenteric lymphatic collectors

SUBMITTER: Dr. René Hägerling 

PROVIDER: S-SCDT-EMBOJ-2017-98271 | biostudies-other |

REPOSITORIES: biostudies-other