Project description:We previously identified a number of genes which were differentially expressed during mitochondrial stress in an ATFS-1-dependent manner using an atfs-1 loss-of-function mutant allele . To complement the findings from our previous microarray, we compared the transcript profiles from wild-type and atfs-1(et18) gain-of-function worms (which have constitutively active ATFS-1) in the absence of mitochondrial stress. We used microarrays to identify genes regulated by ATFS-1 using a gain-of-function allele of atfs-1.

2016-03-21 | GSE73669 | GEO

METTL3 dictates the development of thymocytes via restraining ferroptosis program during age related thymic involution

Project description:Thymic involution is a crucial factor in immune system aging and results in age-related impairment of T cell responses. The control of programmed cell death plays a fundamental role in thymocytes development. How thymocytes cell death contribute to thymic involution remains elusive. In this study, we found that METTL3 is highly expressed in double positive (DP) cells from young mice but decreased in aged mice. Mice conditionally deficiency for METTL3 in T cells showed thymic involution phenotypes with decreased survival and increased senescent DP cells. Additionally, METTL3 deficiency elicited ferroptosis program rather than other cell death pathways and led to defective DP cell development. Furthermore, GPX4, a molecule that protects cells from ferroptosis, was essential for thymocyte survival and preventing senescence. Mechanistically, GPX4 was maintained by METTL3 at the translation level in METTL3 methyltransferase activity independent manner. Targeting METTL3 and ferroptosis process promoted DP cell survival and reinvigorated aged DP cells. These findings reveal the central role of the METTL3-GPX4-ferroptosis axis in regulating thymocyte homeostasis and identifying targets for impeding age-related thymic involution and diseases.

2025-03-01 | GSE243187 | GEO

ERG Activates the YAP1 Transcriptional Program and Induces the Development of Age-Related Prostate Tumors.

Project description: Not available

| S-EPMC4461839 | biostudies-literature

High-Density Lipoproteins Associated with Age-Related Macular Degeneration in the All of Us Research Program.

Project description: Not available

| S-EPMC12097936 | biostudies-literature

Common genetic associations between age-related diseases

Project description: Not available

| S-BSST407 | biostudies-other

Hui2016 - Age-related changes in articular cartilage

Project description: Not available