Dataset Information

Prospective, single-center, interventional follow-up study to determine the effect of prostate carcinoma and its operative therapy on intraocular pressure and determination of potential mediators.

ABSTRACT: Interventions: Group 1: Patients with prostate cancer and planned radical prostatectomy Contact-free examinations: x. Determination of refraction and visual acuity xi. Slit lamp finding (phak / pseudophak), anomalies of the anterior segment affecting the measurability or height of the IOD xii. Pupillometry (pupil width with and without glare, medically unaffected, possibly latency, constriction and dilatation rate) xiii. HRT for glaucoma exclusion xiv. Visante-OCT for corneal thickness measurement Examinations with contact to the eye xv. Intraocular pressure using Pascal tonometer and time of measurement (preferably at 03:00pm +/- 1 hour) xvi. Intraocular pressure using Goldmann tonometer and time of measurement (preferably at 03:00pm +/- 1 hour) Other investigations xvii. Blood sample (if possible, combine with clinical routine blood sampling at the Department of Urology) xviii. urine sample Group 2: Patients without cancer Contact-free examinations: x. Determination of refraction and visual acuity xi. Slit lamp finding (phak / pseudophak), anomalies of the anterior segment affecting the measurability or height of the IOD xii. Pupillometry (pupil width with and without glare, medically unaffected, possibly latency, constriction and dilatation rate) xiii. HRT for glaucoma exclusion xiv. Visante-OCT for corneal thickness measurement Examinations with contact to the eye xv. Intraocular pressure using Pascal tonometer and time of measurement (preferably at 03:00pm +/- 1 hour) xvi. Intraocular pressure using Goldmann tonometer and time of measurement (preferably at 03:00pm +/- 1 hour) Other investigations xvii. Blood sample (if possible, combine with clinical routine blood sampling at the Departme Primary outcome(s): Does the intraocular pressure differ between patients with prostate cancer and a healthy comparison group? Does the intraocular pressure in prostate cancer, breast cancer or colorectal cancer patients change after surgical tumor removal compared to preoperative values? Is there a difference in systemic levels of potential chemical mediator between prostate cancer patients and a healthy comparison group? Do the absolute values and their postoperative change correlate with the intraocular pressure? After completing the recruitment, the data of all four patient groups are evaluated with the program STATISTICA (StatSoft). Study Design: Allocation: Non-randomized controlled study; Masking: Open (masking not used); Control: Other; Assignment: parallel; Study design purpose: diagnostic

DISEASE(S): Primary Open-angle Glaucoma,Prostate Cancer, Mamma Carcinoma, Colorectal Carcinoma

PROVIDER: 2434903 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Dataset Information

Prospective, single-center, interventional follow-up study to determine the effect of prostate carcinoma and its operative therapy on intraocular pressure and determination of potential mediators.

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