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Effect of minimum driving pressure guided individualized ventilation strategy on pulmonary function in elderly patients undergoing laparoscopic colorectal cancer surgery

ABSTRACT: Interventions: Test group:Minimum driving pressure oriented individualized peep;Control group:Traditional fixed PEEP lung protection strategy Primary outcome(s): 7-day PPCS incidence rate (= level 2) Study Design: Parallel

DISEASE(S): Colorectal Cancer

PROVIDER: 40836 | ecrin-mdr-crc |

REPOSITORIES: ECRIN MDR

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Effect of individualized PEEP guided by driving pressure on diaphragm function in patients undergoing laparoscopic radical resection of colorectal cancer

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The effect of individualized titration of positive end expiratory pressure guided by electrical impedance tomography on ventilation distribution during laparoscopic radical resection of colorectal cancer in the elderly

Project description:Interventions: A group:Intervention: The PEEP incremental method for lung recruitment starts with PEEP 5 cmH2O, increasing PEEP 5 cmH2O every 5 breaths until PEEP reaches 20cmH2O and maintaining breathing 10 times. Then decrease PEEP to 5 cmH2O by the reversed operation. After lung recruitment, PEEP titration was performed. PEEP gradually decreased from 20 cmH2O to 4 cmH2O, and decreased by 2 cmH2O every 5 breaths. The PEEP value corresponding to the lowest driving pressure was the optimal PEEP value. The method of lung recruitment is the same as before every 1 hour in the future.;Bgroup:Intervention: The PEEP incremental method of lung recruitment starts with PEEP 5 cmH2O and increases PEEP 5cmH2O every 5 breaths until PEEP reaches 20 cmH2O and maintains breathing for 10 times. Then reverse the operation to decrease PEEP to 5 cmH2O. After lung recruitment, PEEP titration was performed. PEEP gradually decreased from 20 cmH2O to 4 cmH2O, and decreased by 2cmH2O every 5 breaths. The PEEP value corresponding to the lowest driving pressure was the optimal PEEP value. No lung recruitment in the future.;C group:Constant 5cmH2O PEEP Primary outcome(s): global impedance curve amplitude Study Design: Parallel

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The effect of optimal peep lung protection ventilation strategy guided by intraoperative driving pressure on postoperative pulmonary complications in high-risk patients undergoing laparoscopic radical resection of colorectal cancer

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Effect of mechanical ventilation and mechanical ventilationon with positive end expiratory pressure(PEEP) application on diaphragmatic dysfunction in rabbits

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Project description:Intervention group:driving pressure-guided pulmonary protective ventilation combined deep neuromuscular block;Control group:normal pulmonary ventilation combined normal neuromuscular block Primary outcome(s): Postoperative pulmonary complications;Muscle relaxation monitoring Study Design: Parallel

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Driving pressure during proportional assist ventilation: an observational study.

Project description: Not available

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RNA-seq alignment to individualized genomes

2014-06-10 | GSE45684 | GEO

The future of driving pressure: a primary goal for mechanical ventilation?

Project description: Not available

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RNA-seq alignment to individualized genomes

Project description:The source of most errors in RNA sequencing (RNA-seq) read alignment is in the repetitive structure of the genome and not with the alignment algorithm. Genetic variation away from the reference sequence exacerbates this problem causing reads to be assigned to the wrong location. We developed a method, implemented as the software package Seqnature, to construct the imputed genomes of individuals (individualized genomes) of experimental model organisms including inbred mouse strains and genetically unique outbred animals. Alignment to individualized genomes increases read mapping accuracy and improves transcript abundance estimates. In an application to expression QTL mapping, this approach corrected erroneous linkages and unmasked thousands of hidden associations. Individualized genomes accounting for genetic variation will be useful for human short-read sequencing and other sequencing applications including ChIP-seq. Illumina 100bp single-end liver RNA-seq from 277 male and female Diversity Outbred 26-week old mice raised on standard chow or high fat diet. In addition, Illumina 100bp single-end liver RNA-seq from 128 male 26-week old male mice (20 weeks for NZO strain) from each of the DO founder strains raised on standard chow or high fat diet (8 males per strain by diet group). Each sample was sequenced in 2-4x technical replicates across multiple flowcells. Samples were randomly assigned lanes and multiplexed at 12-24x.

2014-06-10 | E-GEOD-45684 | biostudies-arrayexpress

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