Genomics

Dataset Information

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Ena-DATASET-BGI-18-06-2015-04:55:13:301-17 - samples

ABSTRACT: We sequenced 292 patients who were suffering NSCLC with Whole genome sequencing or Exome sequencing method.

PROVIDER: EGAD00001001397 | EGA |

REPOSITORIES: EGA

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Publications

Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas.

Wu Kui K   Zhang Xin X   Li Fuqiang F   Xiao Dakai D   Hou Yong Y   Zhu Shida S   Liu Dongbing D   Ye Xiaofei X   Ye Mingzhi M   Yang Jie J   Shao Libin L   Pan Hui H   Lu Na N   Yu Yuan Y   Liu Liping L   Li Jin J   Huang Liyan L   Tang Hailing H   Deng Qiuhua Q   Zheng Yue Y   Peng Lihua L   Liu Geng G   Gu Xia X   He Ping P   Gu Yingying Y   Lin Weixuan W   He Huiming H   Xie Guoyun G   Liang Han H   An Na N   Wang Hui H   Teixeira Manuel M   Vieira Joana J   Liang Wenhua W   Zhao Xin X   Peng Zhiyu Z   Mu Feng F   Zhang Xiuqing X   Xu Xun X   Yang Huanming H   Kristiansen Karsten K   Wang Jian J   Zhong Nanshan N   Wang Jun J   Pan-Hammarström Qiang Q   He Jianxing J  

Nature communications 20151209

The landscape of genetic alterations in lung adenocarcinoma derived from Asian patients is largely uncharacterized. Here we present an integrated genomic and transcriptomic analysis of 335 primary lung adenocarcinomas and 35 corresponding lymph node metastases from Chinese patients. Altogether 13 significantly mutated genes are identified, including the most commonly mutated gene TP53 and novel mutation targets such as RHPN2, GLI3 and MRC2. TP53 mutations are furthermore significantly enriched i  ...[more]

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