Ena-DATASET-MUO-27-04-2016-12:33:45:301-16 - samples

ABSTRACT: Renal cell carcinoma (RCC) is a genomically heterogeneous tumor. In the present project, the question whether intratumoral heterogeneity follows a zonal pattern indicating spatial niches was addressed. Whole exome sequencing of 16 paired samples from tumor periphery and center revealed a number of region-specific functional SNVs and Indels. Therefore, RCCs are not composed of evenly admixed tumor cells but show topological differences in their clonal composition.

PROVIDER: EGAD00001002067 | EGA |

REPOSITORIES: EGA