Genomics

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Mutational landscape of normal human breast


ABSTRACT: The accumulation of somatic mutations in the healthy breast throughout life and pregnancy is poorly understood. Here we describe whole genome sequencing analysis of epithelial and stromal compartments from the normal breast. We aimed to study how pregnancy and age affect both the mutational burden and the clonality of the healthy breast, and the subsequent implications on breast cancer risk.

PROVIDER: EGAS00001004672 | EGA |

REPOSITORIES: EGA

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