Genomics

Dataset Information

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International Multi-Center ADHD Genetics Project


ABSTRACT: The goal of the project is to complete a 600,000 tag SNP genome-wide association scan of 958 parent-child trios from the International Multisite ADHD Genetics (IMAGE) project, in order to assess the association of SNP markers with ADHD, analyze quantitative ADHD phenotypes, complete copy number analyses, assess parent of origin effects and season of birth effects, and test for epistasis among apparently uncorrelated genes.

Acquiring DNA Samples
All consent forms stipulate that the samples can only be used by researchers who have been approved by the National Institute of Mental Health (NIMH), National Institutes of Health. All consent forms, except those used at the Zürich site (N=141 subjects), explicitly indicate that the samples may be used by researchers from commercial enterprises seeking to benefit financially from the analysis of the samples. The Zürich consent does not prohibit such use. The Zürich consent form also included an "opt out" that allowed the subjects to indicate that they did not want their samples stored at the NIMH repository or used by researchers external to the project. No subjects enrolled in the project opted out.

Consent groups and participant set

  • ADHD (ADHD): 2758 (924 trios)

PROVIDER: phs000016.v2.p2 | EGA |

REPOSITORIES: EGA

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Publications

The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes.

Brookes K K   Xu X X   Chen W W   Zhou K K   Neale B B   Lowe N N   Anney R R   Franke B B   Gill M M   Ebstein R R   Buitelaar J J   Sham P P   Campbell D D   Knight J J   Andreou P P   Altink M M   Arnold R R   Boer F F   Buschgens C C   Butler L L   Christiansen H H   Feldman L L   Fleischman K K   Fliers E E   Howe-Forbes R R   Goldfarb A A   Heise A A   Gabriëls I I   Korn-Lubetzki I I   Johansson L L   Marco R R   Medad S S   Minderaa R R   Mulas F F   Müller U U   Mulligan A A   Rabin K K   Rommelse N N   Sethna V V   Sorohan J J   Uebel H H   Psychogiou L L   Weeks A A   Barrett R R   Craig I I   Banaschewski T T   Sonuga-Barke E E   Eisenberg J J   Kuntsi J J   Manor I I   McGuffin P P   Miranda A A   Oades R D RD   Plomin R R   Roeyers H H   Rothenberger A A   Sergeant J J   Steinhausen H-C HC   Taylor E E   Thompson M M   Faraone S V SV   Asherson P P  

Molecular psychiatry 20060808 10


Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studies have demonstrated the importance of genetic factors and candidate gene association studies have identified several loci that exert small but significant effects on ADHD. To provide further clarification of reported associations and identify novel associated genes, we examined 1,038 single-nucleotide po  ...[more]

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