Ontology highlight
ABSTRACT: The goal of the project is to identify genes that make individuals more susceptible to bipolar disorder (manic depressive illness) and to better understand the brain pathways involved in the disease. Dataset versioning Consent groups and participant set
This consent group includes all controls for the Bipolar study, which are a subset of controls for the Schizophrenia study (subset of Schizophrenia: GRU).
This consent group includes a subset of the Bipolar cases.
This consent group includes a subset of the Bipolar cases.
PROVIDER: phs000017.v3.p1 | EGA |
REPOSITORIES: EGA
McInnis Melvin G MG Dick Danielle M DM Willour Virginia L VL Avramopoulos Dimitrios D MacKinnon Dean F DF Simpson Sylvia G SG Potash James B JB Edenberg Howard J HJ Bowman Elizabeth S ES McMahon Francis J FJ Smiley Carrie C Chellis Jennifer L JL Huo Yuqing Y Diggs Tyra T Meyer Eric T ET Miller Marvin M Matteini Amy T AT Rau N Leela NL DePaulo J Raymond JR Gershon Elliot S ES Badner Judith A JA Rice John P JP Goate Alison M AM Detera-Wadleigh Sevilla D SD Nurnberger John I JI Reich Theodore T Zandi Peter P PP Foroud Tatiana M TM
Biological psychiatry 20031201 11
<h4>Background</h4>In 1989 the National Institute of Mental Health began a collaborative effort to identify genes for bipolar disorder. The first 97 pedigrees showed evidence of linkage to chromosomes 1, 6, 7, 10, 16, and 22 (Nurnberger et al 1997). An additional 56 bipolar families have been genotyped, and the combined sample of 153 pedigrees studied.<h4>Methods</h4>Three hierarchical affection status models were analyzed with 513 simple sequence repeat markers; 298 were common across all pedig ...[more]