Dataset Information
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS nonGAIN)
Ontology highlight
ABSTRACT: This study is part of the Molecular Genetics of Schizophrenia (MGS) genome wide association study (GWAS) of 3,972 cases
(2,686 EA and 1,286 AA) and 3,629 controls (2,656 EA and 973 AA) (analyzed sample remaining after quality control exclusions),
comprised of European ancestry (EA) and African American (AA) samples. We genotyped about half of the EA sample and almost all
of the AA sample under the auspices of the Genetic Association Information Network (GAIN) with the Affymetrix 6.0 platform at the
Broad Institute. The remainder of the included sample was also genotyped with the Affymetrix 6.0 platform at the Broad Institute,
and we refer to this component as the nonGAIN sample. Cases met criteria for schizophrenia (SCZ) or schizoaffective disorder
(SA) per the Diagnostic and Statistical Manual of Mental Disorders version IV (DSM-IV) for all three collections (SGI, MGS1,
and MGS2) comprising these cases. However, for the older SGI collection, codes for the secondary diagnoses refer to the older
DSM-III-R version. Controls were screened briefly and excluded if they endorsed a history of these illnesses.
PROVIDER: phs000167.v1.p1 | EGA |
REPOSITORIES: EGA
Publications
Common variants on chromosome 6p22.1 are associated with schizophrenia.
Nature 20090701 7256
Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5-1%, with high heritability (80-85%) and complex transmission. Recent studies implicate rare, large, high-penetrance copy number variants in some cases, but the genes or biological mechanisms that underlie susceptibility are not known. Here we show that schizophrenia is significantly associated with single nucleotide polymorphisms (SNPs) in the extended major histocompatibility complex region on chromosome 6. We carried ou ...[more]
