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Genome-Wide Association Study of Schizophrenia

ABSTRACT:

The goal of the study is to find susceptibility genes for schizophrenia.

Dataset versioning

Version 1: European-American (EA) ancestry only
Version 2: Version 1 plus African-American (AA) ancestry

Consent groups and participant set

General research use (GRU): 4591 cases and controls (1217 EA cases, 1442 EA controls, 953 AA cases, 979 AA controls)
This consent group includes a subset of schizophrenia cases and all controls (which overlap with Bipolar study controls in Bipolar: GRU dataset).
Schizophrenia and related disorders (SARC): 475 cases (187 EA cases, 288 AA cases)
This consent group includes a subset of schizophrenia cases.

PROVIDER: phs000021.v3.p2 | EGA |

REPOSITORIES: EGA

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Publications

Common variants on chromosome 6p22.1 are associated with schizophrenia.

Shi Jianxin J Levinson Douglas F DF Duan Jubao J Sanders Alan R AR Zheng Yonglan Y Pe'er Itsik I Dudbridge Frank F Holmans Peter A PA Whittemore Alice S AS Mowry Bryan J BJ Olincy Ann A Amin Farooq F Cloninger C Robert CR Silverman Jeremy M JM Buccola Nancy G NG Byerley William F WF Black Donald W DW Crowe Raymond R RR Oksenberg Jorge R JR Mirel Daniel B DB Kendler Kenneth S KS Freedman Robert R Gejman Pablo V PV

Nature 20090701 7256

Schizophrenia, a devastating psychiatric disorder, has a prevalence of 0.5-1%, with high heritability (80-85%) and complex transmission. Recent studies implicate rare, large, high-penetrance copy number variants in some cases, but the genes or biological mechanisms that underlie susceptibility are not known. Here we show that schizophrenia is significantly associated with single nucleotide polymorphisms (SNPs) in the extended major histocompatibility complex region on chromosome 6. We carried ou ...[more]

PMID: 19571809

Publication: 1/8

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