Dataset Information


Dynamic regulation of T Follicular Regulatory (Tfr) cell responses by IL-2 during influenza infection

ABSTRACT: We found that approximately 2,000 genes were differentially expressed between conventional Treg and Tfr cells following influenza virus infection Overall design: We conducted an RNA-seq analysis on sorted conventional Treg cells (FoxP3+CD69hiPD1loCXCR5loCD25hi) and Tfr cells (FoxP3+CD69hiPD1hiCXCR5hiCD25lo) obtained from the mediastinal lymph node (mLN) of day 30 infected B6.FoxP3-DTR/GFP mice. This analysis was performed to identify and quantify differentially-expressed genes and differentially-enriched signaling pathways between the two T cell subsets.

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Andre Ballesteros-Tato  

PROVIDER: GSE101016 | GEO | 2017-08-30



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Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.

Botta Davide D   Fuller Michael J MJ   Marquez-Lago Tatiana T TT   Bachus Holly H   Bradley John E JE   Weinmann Amy S AS   Zajac Allan J AJ   Randall Troy D TD   Lund Frances E FE   León Beatriz B   Ballesteros-Tato André A  

Nature immunology 20170911 11

Interleukin 2 (IL-2) promotes Foxp3+ regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some Treg cells downre  ...[more]

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