Transcriptomics,Genomics

Dataset Information

184

Dynamic regulation of T Follicular Regulatory (Tfr) cell responses by IL-2 during influenza infection


ABSTRACT: We found that approximately 2,000 genes were differentially expressed between conventional Treg and Tfr cells following influenza virus infection Overall design: We conducted an RNA-seq analysis on sorted conventional Treg cells (FoxP3+CD69hiPD1loCXCR5loCD25hi) and Tfr cells (FoxP3+CD69hiPD1hiCXCR5hiCD25lo) obtained from the mediastinal lymph node (mLN) of day 30 infected B6.FoxP3-DTR/GFP mice. This analysis was performed to identify and quantify differentially-expressed genes and differentially-enriched signaling pathways between the two T cell subsets.

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Andre Ballesteros-Tato  

PROVIDER: GSE101016 | GEO | 2017-08-30

SECONDARY ACCESSION(S): PRJNA393591

REPOSITORIES: GEO

altmetric image

Publications

Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection.

Botta Davide D   Fuller Michael J MJ   Marquez-Lago Tatiana T TT   Bachus Holly H   Bradley John E JE   Weinmann Amy S AS   Zajac Allan J AJ   Randall Troy D TD   Lund Frances E FE   León Beatriz B   Ballesteros-Tato André A  

Nature immunology 20170911 11


Interleukin 2 (IL-2) promotes Foxp3+ regulatory T (Treg) cell responses, but inhibits T follicular helper (TFH) cell development. However, it is not clear how IL-2 affects T follicular regulatory (TFR) cells, a cell type with properties of both Treg and TFH cells. Using an influenza infection model, we found that high IL-2 concentrations at the peak of the infection prevented TFR cell development by a Blimp-1-dependent mechanism. However, once the immune response resolved, some Treg cells downre  ...[more]

Similar Datasets

2015-09-02 | E-GEOD-69756 | ArrayExpress
2013-12-15 | E-GEOD-50094 | ArrayExpress
| GSE87130 | GEO
2017-04-28 | E-GEOD-76138 | ArrayExpress
2012-08-30 | E-GEOD-40443 | ArrayExpress
| GSE93670 | GEO
| GSE78190 | GEO
2013-03-07 | E-GEOD-42021 | ArrayExpress
2013-12-15 | E-GEOD-50097 | ArrayExpress
2018-05-18 | PXD007744 | Pride