Dataset Information


A Comparison of the Sexually Dimorphic Pravastatin Transcriptome in Mouse Cerebral Cortical Embryonic Neural Stem Cells

ABSTRACT: We used RNA-Seq analysis to identify the sexually dimorphic pravastatin regulated gene expression profile in primary cultures of mouse embryonic cerebral cortical neural progenitor/stem cells. Overall design: RNAseq on primary E14.5 mouse cerebral cortical neurosphere cultures. 4 conditions - Male Cortex Pravastatin, Male Cortex Vehicle, Female Cortex Pravastatin, Female Cortex Vehicle. There are 3 biological replicates for each condition and all the 12 samples were run on two lanes (technical duplicates).

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

SUBMITTER: Uma Chandran  

PROVIDER: GSE111945 | GEO | 2018-04-25


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Statins impact primary embryonic mouse neural stem cell survival, cell death, and fate through distinct mechanisms.

Carson Ross A RA   Rudine Anthony C AC   Tally Serena J SJ   Franks Alexis L AL   Frahm Krystle A KA   Waldman Jacob K JK   Silswal Neerupma N   Burale Suban S   Phan James V JV   Chandran Uma R UR   Monaghan A Paula AP   DeFranco Donald B DB  

PloS one 20180508 5

Statins inhibit HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthesis pathway (CBP), and are used for the prevention of cardiovascular disease. The anti-inflammatory effects of statins may also provide therapeutic benefits and have led to their use in clinical trials for preeclampsia, a pregnancy-associated inflammatory condition, despite their current classification as category X (i.e. contraindicated during pregnancy). In the developing neocortex, products of the CBP play  ...[more]

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