Genomics

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MRNA-Seq of mouse Mettl3 cKO and Fto cKO hippocampus after fear conditioning


ABSTRACT: N6-Methyladenosine (m6A) and N6,2′-O-dimethyladenosine (m6Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of both, here termed m6A/m, in the stress response in the adult brain in vivo are currently unknown. Here, we investigated the effect of gene deletion of Mettl3, a m6A methyltransferase, and Fto, a m6A and m6Am demethlyase, induced in adulthood in excitatory neurons of the CA1 and CA3 in the hippocampus (Nex-CreERT2 Mettl3 or Fto cKO) on the transcriptome of CA1 and CA3 as well as the transcriptomic response of the CA1 and CA3 transcriptome to fear conditioning. Overall design: 5 biological replicates each for CA1/3 of Nex-CreERT2 Mettl3 wild type ("WT") and conditional knock-out mice ("cKO") or Nex-CreERT2 Fto WT and cKO, each at baseline("Box") or 24 h after fear conditioning ("FC").

INSTRUMENT(S): Illumina HiSeq 4000 (Mus musculus)

SUBMITTER: Mareen Engel  

PROVIDER: GSE113796 | GEO | 2018-07-10

REPOSITORIES: GEO

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