Dataset Information


MRNA-Seq of mouse Mettl3 cKO and Fto cKO hippocampus after fear conditioning

ABSTRACT: N6-Methyladenosine (m6A) and N6,2′-O-dimethyladenosine (m6Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of both, here termed m6A/m, in the stress response in the adult brain in vivo are currently unknown. Here, we investigated the effect of gene deletion of Mettl3, a m6A methyltransferase, and Fto, a m6A and m6Am demethlyase, induced in adulthood in excitatory neurons of the CA1 and CA3 in the hippocampus (Nex-CreERT2 Mettl3 or Fto cKO) on the transcriptome of CA1 and CA3 as well as the transcriptomic response of the CA1 and CA3 transcriptome to fear conditioning. Overall design: 5 biological replicates each for CA1/3 of Nex-CreERT2 Mettl3 wild type ("WT") and conditional knock-out mice ("cKO") or Nex-CreERT2 Fto WT and cKO, each at baseline("Box") or 24 h after fear conditioning ("FC").

INSTRUMENT(S): Illumina HiSeq 4000 (Mus musculus)

SUBMITTER: Mareen Engel  

PROVIDER: GSE113796 | GEO | 2018-07-10


Dataset's files

Action DRS
GSE113796_processed_data_files.tar.gz Other
Items per page:
1 - 1 of 1

Similar Datasets

2018-07-10 | GSE113793 | GEO
2018-01-01 | S-EPMC6151148 | BioStudies
2019-01-01 | S-EPMC6386707 | BioStudies
2018-01-01 | S-EPMC6069762 | BioStudies
2019-01-01 | S-EPMC6621992 | BioStudies
2019-01-01 | S-EPMC6904561 | BioStudies
2017-01-01 | S-EPMC5513158 | BioStudies
2017-01-01 | S-EPMC5479356 | BioStudies
2018-01-01 | S-EPMC6021109 | BioStudies
2020-01-01 | S-EPMC7334764 | BioStudies