Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)
ORGANISM(S): Homo Sapiens
SUBMITTER: Alexander Ploss
PROVIDER: GSE119749 | GEO | 2018-11-28
REPOSITORIES: GEO
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Douam Florian F Ziegler Carly G K CGK Hrebikova Gabriela G Fant Bruno B Leach Robert R Parsons Lance L Wang Wei W Gaska Jenna M JM Winer Benjamin Y BY Heller Brigitte B Shalek Alex K AK Ploss Alexander A
Nature communications 20181128 1
Mice engrafted with components of a human immune system have become widely-used models for studying aspects of human immunity and disease. However, a defined methodology to objectively measure and compare the quality of the human immune response in different models is lacking. Here, by taking advantage of the highly immunogenic live-attenuated yellow fever virus vaccine YFV-17D, we provide an in-depth comparison of immune responses in human vaccinees, conventional humanized mice, and second gene ...[more]