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A20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE128249 | GEO | 2020/02/20

REPOSITORIES: GEO

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A20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death [mouse]

Project description:A20 is known key regulator of NF-κB activity and inflammatory response, but its role in the control of cell death receptor signaling is not completely understood. Although A20 is widely accepted anti-apoptotic protein, we demonstrate that elevated expression of A20 in both, human and murine keratinocytes results in sensitisation to TNF-induced cell death. We prove that the Ripoptosome formation in A20 overexpressing cells is prerequisite for the TNF-induced cell death execution. We demonstrate that both canonical and non-canonical NF-κB signaling pathways are regulated upon increase of A20 expression. A20 dependent alteration of cIAPs and TRAF1 expressions are involved in the multiple level control of cell death in keratinocytes with elevated A20 expression.

2020-02-20 | GSE128248 | GEO

A20 contribution to NF-κB regulation, Ripoptosome formation and TNF-induced cell death [human]

2020-02-20 | GSE128247 | GEO