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Effects of extensive fasting and subsequent feeding on hepatic transcription

ABSTRACT: Temporally restricted feeding has a profound effect on the circadian clock. Fasting and feeding paradigms are known to influence hepatic transcription. This dataset shows the dynamic effects of refeeding mice after a 24hour fasting period.

ORGANISM(S): Mus musculus

PROVIDER: GSE13063 | GEO | 2009/11/23

SECONDARY ACCESSION(S): PRJNA114079

REPOSITORIES: GEO

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Effects of extensive fasting and subsequent feeding on hepatic transcription

Project description:Temporally restricted feeding has a profound effect on the circadian clock. Fasting and feeding paradigms are known to influence hepatic transcription. This dataset shows the dynamic effects of refeeding mice after a 24hour fasting period. Mice were entrained for two weeks under ad libitum access to food. Mice were then released into constant darkness and food was withdrawn at CT4 on the first day in constant darkness. On the second day in constant darkness mice were either fed (Refed) or continously fasted (Fast) at CT4. Liver tissue was collected at the indicated timepoints. Total RNA was extracted and standard Affymetrix protocol were used for amplification, labeling and hybridization

2009-11-23 | E-GEOD-13063 | biostudies-arrayexpress

Effects of extensive fasting on hepatic transcription

2009-11-23 | GSE13064 | GEO

Effects of extensive fasting on hepatic transcription

Project description:Temporally restricted feeding has a profound effect on the hepatic circadian clock. While the circadian clock is largely unaffected by by extensive fasting, many transcripts are known to be affected by a fasting paradigm. This dataset shows the effect of extensive fasting on dynamic gene expression in the liver C57/B6 mice were entrained to ad libitum feeding schedule for two weeks. They were then released into constant were food was withdrawn at CT16. On the second day in constant darkness tissue was collected at the indicated timepoints. Total RNA was extracted and 5ug of total RNA was used for the standard Affymetrix protocol of amplification, labeling and hybridization

2009-11-23 | E-GEOD-13064 | biostudies-arrayexpress

Effect of fasting-refeeding on gene expression in young and old killifsh adipose tissue.

Project description:Fasting-refeeding paradigms result in drastic shifts in metabolism and gene expression patterns. The effect of fasting-refeeding changes between young and old individuals. We sought to decipher the changes in response to fasting-refeeding in young and old animals by profiling gene expression in adipose tissue of killifish Nothobranchius furzeri.

2025-05-10 | GSE296348 | GEO

Liver X receptor controls a bifurcated transcriptional program where lipogenesis genes overshoot upon refeeding while cholesterol biosynthesis genes return to pre-fasting levels [lxr_rna]

Project description:Transitions from a fed to a fasted state are common in mammals. The liver orchestrates adaptive responses to feeding/fasting by transcriptionally regulating metabolic pathways of energy usage and storage. Transcriptional and enhancer dynamics following cessation of fasting (refeeding) were never explored. We aimed to inspect the transcriptional and chromatin events occurring upon refeeding, their kinetic behavior and their molecular drivers. We found that the refeeding response is temporally-organized with an early response focused on ramping up protein translation while later stages of refeeding drive a bifurcated lipid synthesis program. While both lipid synthesis pathways were inhibited during fasting, cholesterol biosynthesis genes returned to their basal levels upon refeeding while lipogenesis genes significantly overshoot above pre-fasting levels. Lipogenic gene overshoot is dictated by Liver X Receptor alpha (LXRα) which directly binds and activates lipogenic enhancers. These findings unravel the mechanism behind the long-known phenomenon of refeeding fat overshoot.

2024-07-10 | GSE243054 | GEO

Liver X receptor controls a bifurcated transcriptional program where lipogenesis genes overshoot upon refeeding while cholesterol biosynthesis genes return to pre-fasting levels [lxr_atac]

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Liver X receptor controls a bifurcated transcriptional program where lipogenesis genes overshoot upon refeeding while cholesterol biosynthesis genes return to pre-fasting levels [kinetics_rna]

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Liver X receptor controls a bifurcated transcriptional program where lipogenesis genes overshoot upon refeeding while cholesterol biosynthesis genes return to pre-fasting levels [lxr_chip]

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Feeding schedule and the circadian clock shape rhythms in hepatic gene expression

Project description:This SuperSeries is composed of the following subset Series: GSE13060: The effects of temporally restricted feeding on hepatic gene expression GSE13062: The effects of temporally restricted feeding on hepatic gene expression of Cry1, Cry2 double KO mice GSE13063: Effects of extensive fasting and subsequent feeding on hepatic transcription GSE13064: Effects of extensive fasting on hepatic transcription Refer to individual Series

2009-11-12 | E-GEOD-13093 | biostudies-arrayexpress

ATAC-sequencing to evaluate the global chromatin dynamics in the absence of hepatic-HMGB1 in livers from mice on fed with chow diet or after a metabolic stress induced by a fasting (6hours)-refeeding (8hours) challenge.

Project description:Hepatocyte nuclei were purified from liver samples harvested from HMGB1fl/fl (n=2) and HMGB1ΔHep (n=2) mice upon chow diet feeding or after fasting-refeeding.

2022-03-31 | E-MTAB-11542 | biostudies-arrayexpress

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