Dataset Information
Feeding schedule and the circadian clock shape rhythms in hepatic gene expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Christopher Vollmers
PROVIDER: E-GEOD-13093 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression.
Proceedings of the National Academy of Sciences of the United States of America 20091125 50
In mammals, the circadian oscillator generates approximately 24-h rhythms in feeding behavior, even under constant environmental conditions. Livers of mice held under constant darkness exhibit circadian rhythm in abundance in up to 15% of expressed transcripts. Therefore, oscillations in hepatic transcripts could be driven by rhythmic food intake or sustained by the hepatic circadian oscillator, or a combination of both. To address this question, we used distinct feeding and fasting paradigms on ...[more]
