Genomics

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Analysis of the role of Mcu in the regenerating mouse liver after partial hepatectomy


ABSTRACT: In this study, we analyzed global liver gene expression in MCU knock-down (KD) mice. MCUloxp/loxp male mice were treated with an AAV8-Cre under the control of a hepatocyte specific promoter (TBG) to generate liver-specific MCU KD mice. AAV8-TBG-Null treated littermates were used as controls. Knockdown was verified 3 weeks after injection by protein and mRNA (80%). 5 weeks after injection mice were subjected to 70% partial hepatectomy and liver semples were collected 30h after the sugery. Mouse Clariom S (Affymetrix, Santa Clara, CA) arrays were used to obtain global gene expression data from pooled liver samples (pools of 4 biological replicates per array). Overall design: Gene expression was profiled in the regenerating livers of wild type and in liver-specific MCU knockdown mice at t=0 and 30h after 70% partial hepatectomy; pools of 4 biological replicates per genotype.

INSTRUMENT(S): [Clariom_S_Mouse] Affymetrix Mouse Clariom S Array

ORGANISM(S): Mus musculus  

SUBMITTER: Egle Juskeviciute 

PROVIDER: GSE137891 | GEO | 2020-01-01

REPOSITORIES: GEO

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