Transcriptomics

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GATA2 tumor suppressive role revealed in ERG - AML mouse model, unveiling a preleukemic phenotype


ABSTRACT: The transcription factor (TF) GATA2, is crucial for the formation, and lifelong homeostasis of hematopoietic stem cells. Mono-Allelic germline disruptions of GATA2, result in haploinsufficiency syndromes. These disorders display variable manifestations, including immune deficiency, lymphedema, pulmonary proteinosis, and bone marrow failure. The later is presented by myelodysplastic changes (MDS), that subsequently evolve to leukemia (AML). MDS/AML are the most devastating, yet most consistent outcomes, designating GATA2 deficiency as one major predisposing condition to AML development.

ORGANISM(S): Mus musculus

PROVIDER: GSE143308 | GEO | 2023/09/15

REPOSITORIES: GEO

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