Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HumanMethylation450 BeadChip (HumanMethylation450_15017482)
ORGANISM(S): Homo sapiens
SUBMITTER: Boris Bartholdy
PROVIDER: GSE144894 | GEO | 2020-03-16
REPOSITORIES: GEO
Action | DRS | |||
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GSE144894_RAW.tar | Raw | |||
GSE144894_Raw_beta-_and_p-values_GEO.txt.gz | Txt | |||
filelist.txt | Txt |
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Bartholdy Boris A BA Wang Xiahoua X Yan Xiao-Jie XJ Pascual Marién M Fan Manxia M Barrientos Jacqueline J Allen Steven L SL Martinez-Climent Jose Angel JA Rai Kanti R KR Chiorazzi Nicholas N Scharff Matthew D MD Roa Sergio S
Blood advances 20200301 5
Intraclonal subpopulations of circulating chronic lymphocytic leukemia (CLL) cells with different proliferative histories and reciprocal surface expression of CXCR4 and CD5 have been observed in the peripheral blood of CLL patients and named proliferative (PF), intermediate (IF), and resting (RF) cellular fractions. Here, we found that these intraclonal circulating fractions share persistent DNA methylation signatures largely associated with the mutation status of the immunoglobulin heavy chain ...[more]