Genomics

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Transcriptomic profiling identifies unique and shared functions of oncogenic KRAS and RIT1


ABSTRACT: Aberrant activation of RAS oncogenes is a prevalent event in lung adenocarcinoma, with somatic mutation of KRAS occurring in ~30% of tumors. Recently, we identified somatic mutation of the RAS-family GTPase RIT1 in lung adenocarcinoma, but relatively little is known about the biological pathways regulated by RIT1 and how these relate to the oncogenic KRAS network. Here we present (quantitative proteomic and) transcriptomic profiles from KRAS-mutant and RIT1-mutant isogenic lung epithelial cells and globally characterize the signaling networks regulated by each oncogene.

ORGANISM(S): Homo sapiens

PROVIDER: GSE146479 | GEO | 2020/03/06

REPOSITORIES: GEO

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