Transcriptomics

Dataset Information

25

Differential expression of microRNAs in the placentae of Chinese patients with severe pre-eclampsia


ABSTRACT: To determine differential expression of microRNAs in placentae with severe pre-eclampsia and normal placenta. Differential expression of microRNAs in placentae (4 severe pre-eclampsia and 4 normal control) was screened by microarray platform, then some differential microRNAs were selected and validated with real-time quantitative reverse transcription polymerase chain reaction in placentae of severe pre-eclampsia (n=24) and normal control group (n=26). Results: We validated the expression of some microRNAs altered in the microarray, and found the following microRNAs were significantly increased in severe pre-eclampsia placentae: miR-16, miR-29b, miR-195, miR-26b, miR-181a, miR-335 and miR-222. Conclusion: These differential microRNAs may play an important role in pathogenesis of pre-eclampsia. Overall design: We analyzed the microRNA expression in the placentae of Chinese patients with severe pre-eclampsia.

INSTRUMENT(S): Capitalbio mammal microRNA V3.0

ORGANISM(S): Homo sapiens  

SUBMITTER: Jianqing Zhao  

PROVIDER: GSE15789 | GEO | 2011-04-14

SECONDARY ACCESSION(S): PRJNA116869

REPOSITORIES: GEO

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