Project description:Activation of the Sonic hedgehog (Shh) signaling pathway due to Patched 1 (PTCH1) mutation is a key event in sporadic and familial basal cell carcinoma (BCC) development. To find out the specific pathway for therapeutic intervention, we developed a mouse BCC model by skin specific Ptch1 inactivation, and sought to identify novel Shh targets. We used microarrays to identify up-regulated genes in mouse BCC. We used microarrays to identify down-regulated genes in mouse BCC cell line by cyclopamine.
Project description:The goal of these ATAC-seq experiments was to determine changes in chromatin accesiblity caused by Il1a and Osm ligand treatment of mouse BCC cells at 48h timepoint versus PBS control
Project description:The goal of these RNA-seq experiments was to determine transcriptomic gene expression changes caused by Il1 or Osm (or both) treatments of mouse BCC cells at 24h and 48h timepoints versus PBS control
Project description:The goal of these RNA-seq experiments was to determine transcriptomic gene expression changes caused by 7 days of Il1a and Osm combination treatment of mouse primary BCC tumor-derived organoids compared to PBS control
