Project description:Activation of the Sonic hedgehog (Shh) signaling pathway due to Patched 1 (PTCH1) mutation is a key event in sporadic and familial basal cell carcinoma (BCC) development. To find out the specific pathway for therapeutic intervention, we developed a mouse BCC model by skin specific Ptch1 inactivation, and sought to identify novel Shh targets. We used microarrays to identify up-regulated genes in mouse BCC. We used microarrays to identify down-regulated genes in mouse BCC cell line by cyclopamine.
Project description:<p>Laser ablation rapid evaporative ionisation mass spectrometry (LA-REIMS) was used to analyse human basal cell carcinoma (BCC) samples. 14 samples are presented here, along with H&E-stained histological images.</p>