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Transcriptional network controlled by Candida albicans treated by otilonium bromide (OB)

ABSTRACT: To investigate potential target of otilonium bromide in C. albicans, we conducted the RNA-sequencing and found 145 genes with significantly different gene expressions (DGEs), which represented equal to or more than 2 fold-change in gene expression. Among these genes, there were 109 genes showing up-regulated in C. albicans treated with 0.5 μg/mL OB, and the other 36 were down-regulated. Main functions of these genes included oxidoreductase activity, heme binding and tetrapyrrole binding, and all functions analyzed from gene ontology indicated metal ion might play a critical role in otilonium bromide-mediated gene regulation.

ORGANISM(S): Candida albicans

PROVIDER: GSE189386 | GEO | 2026/01/12

REPOSITORIES: GEO

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