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Identification and characterization of BEND2 as a novel and key regulator of meiosis during mouse spermatogenesis [BEND2_ChIPseq]


ABSTRACT: To characterize BEND2-binding sites on the genome, we conducted ChIP-seq analyses by using testicular lysates from FLAG-BEND2 KI mice. We found BEND2 preferentially binds to simple sequence repeats. Overall design: Ttesticular tissues from 15 dpp or 40 dpp FLAG-BEND2 mice were performed in each experiment. ChIP-seq data analyses were based on six independent replications.

INSTRUMENT(S): Illumina NovaSeq 6000 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: Chunsheng Han  

PROVIDER: GSE189594 | GEO | 2022-06-01

REPOSITORIES: GEO

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Identification and characterization of BEND2 as a key regulator of meiosis during mouse spermatogenesis.

Ma Longfei L   Xie Dan D   Luo Mengcheng M   Lin Xiwen X   Nie Hengyu H   Chen Jian J   Gao Chenxu C   Duo Shuguang S   Han Chunsheng C  

Science advances 20220525 21


The chromatin state, which undergoes global changes during spermatogenesis, is critical to meiotic initiation and progression. However, the key regulators involved and the underlying molecular mechanisms remain to be uncovered. Here, we report that mouse BEND2 is specifically expressed in spermatogenic cells around meiotic initiation and that it plays an essential role in meiotic progression. <i>Bend2</i> gene knockout in male mice arrested meiosis at the transition from zygonema to pachynema, d  ...[more]

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