Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina NovaSeq 6000 (Mus musculus)
ORGANISM(S): Mus Musculus
SUBMITTER: Chunsheng Han
PROVIDER: GSE189594 | GEO | 2022-06-01
REPOSITORIES: GEO
Ma Longfei L Xie Dan D Luo Mengcheng M Lin Xiwen X Nie Hengyu H Chen Jian J Gao Chenxu C Duo Shuguang S Han Chunsheng C
Science advances 20220525 21
The chromatin state, which undergoes global changes during spermatogenesis, is critical to meiotic initiation and progression. However, the key regulators involved and the underlying molecular mechanisms remain to be uncovered. Here, we report that mouse BEND2 is specifically expressed in spermatogenic cells around meiotic initiation and that it plays an essential role in meiotic progression. <i>Bend2</i> gene knockout in male mice arrested meiosis at the transition from zygonema to pachynema, d ...[more]