Transcriptomics,Genomics

Dataset Information

35

Mapping the Burkholderia cenocepacia niche response via high-throughput sequencing


ABSTRACT: Transcriptional profiling of RNA-seq data from two Burkholderia species grown under conditions mimicking the cystic fibrosis lung and the soil environment Overall design: Two condition, two strain experiment. Biological replicates: 2 replicates

INSTRUMENT(S): Illumina Genome Analyzer (Burkholderia cenocepacia)

SUBMITTER: Deborah R. Yoder-Himes 

PROVIDER: GSE19115 | GEO | 2009-11-21

SECONDARY ACCESSION(S): PRJNA120467

REPOSITORIES: GEO

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Publications

Mapping the Burkholderia cenocepacia niche response via high-throughput sequencing.

Yoder-Himes D R DR   Chain P S G PS   Zhu Y Y   Wurtzel O O   Rubin E M EM   Tiedje James M JM   Sorek R R  

Proceedings of the National Academy of Sciences of the United States of America 20090220 10


Determining how an organism responds to its environment by altering gene expression is key to understanding its ecology. Here, we used RNA-seq to comprehensively and quantitatively assess the transcriptional response of the bacterial opportunistic cystic fibrosis (CF) pathogen and endemic soil dweller, Burkholderia cenocepacia, in conditions mimicking these 2 environments. By sequencing 762 million bases of cDNA from 2 closely related B. cenocepacia strains (one isolated from a CF patient and on  ...[more]

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