Phf6 mutation induces leukemogenesis through altered chromatin state in mice (RNA-Seq)

ABSTRACT: To investigate the effect of PHF6 mutations in leukemogenesis, we generated Phf6R274X transgenetic(Tg) and Phf6 KO mice. Then we purified the Lineage-cKit+Sca-1+ cells from bone marrow of Phf6R274XTg, Phf6 KO and WT mice, and performed bulk RNA-seq to profile the transcriptom.

ORGANISM(S): Mus musculus

PROVIDER: GSE198499 | GEO | 2026/06/01

REPOSITORIES: GEO