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Type I interferons govern Zika virus resistance of human macrophages and microglia

ABSTRACT: The role of the human type I interferon (IFN-I) system in restricting Zika virus (ZIKV) is uncertain. Here, genetic and pharmacological ablation of IFN-I signalling enhanced ZIKV replication and cytopathicity in macrophages and microglia, key cells in ZIKV transmission and pathogenesis. Thus, despite the extensive IFN-I countermeasures employed by ZIKV, IFN-I dictates the outcome of infection in macrophages. Therapeutic manipulation of the IFN-I system may bring clinical benefit in ZIKV.

ORGANISM(S): Homo sapiens

PROVIDER: GSE198542 | GEO | 2022/10/31

REPOSITORIES: GEO

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