Transcriptomics

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Single cell multiomic landscape reveals gene programs driving lipid droplet heterogeneity in hepatic steatosis


ABSTRACT: Alcohol-associated liver disease (ALD) in its earliest form is evidenced as hepatic steatosis which may progress to liver cirrhosis. Using single-cell multiomics technology, we studied transcriptional mechanisms across the hepatic lobule that could account for liver zonation of lipid droplets in a murine ALD model. Furthermore, chromatin landscape studies demonstrated zonation of regulatory elements and master transcription factors associated with these changes in the transcriptome.

ORGANISM(S): Mus musculus

PROVIDER: GSE199064 | GEO | 2026/04/01

REPOSITORIES: GEO

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