Transcriptomic analysis of normal and Ino-RNA treated cells.
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ABSTRACT: During virus infections, host machinery is mobilized to defend against the invading pathogen. The recognition of a viral infection is accomplished by interaction of viral components with host cells. Viral proteins and double-stranded RNA have been previously reported to be potent activator of host cells. We have identified that recognition of virus infections by host cells is the presence of inosines in RNA, which is rare under normal growing conditions but is significantly increased during virus infections. This recognition leads to a robust activation of innate immune responses both in vitro in human epithelial cell cultures and in vivo in a mouse model. This study uncovers a novel structure for activation of innate immune responses during virus infections.
ORGANISM(S): Homo sapiens
PROVIDER: GSE20936 | GEO | 2012/02/09
SECONDARY ACCESSION(S): PRJNA124381
REPOSITORIES: GEO
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