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B cell fate mapping reveals their contribution to the memory immune response against helminths

ABSTRACT: To identify B cell memory in the response against helminths we used a fate-mapping aproach using inducible Cre to label B cells participating in the immune response against Nippostrongylus brasiliensis. We transferred our marked cells into wild-type recipient mice and compared the cells before and after the transfer.

ORGANISM(S): Mus musculus

PROVIDER: GSE209523 | GEO | 2022/11/15

REPOSITORIES: GEO

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Single CD4+ cells after Nippostrongylus brasiliensis infection

Project description:We were interested in investigating the heterogeneity of CD4+ Th2 cells during infection response. In order to do so we injected Nippostrongylus brasiliensis (Nb) in recipient mice as this is known to elicit a Type 2 response. Mice were subcutaneously injected with Nb larvae and single CD4+ cells were isolated from mediastinal lymph nodes, mesenteric lymph nodes, and lungs 5 days after infection.

2016-04-13 | E-MTAB-4619 | biostudies-arrayexpress

Transcription profiling of lungs from SCID and wild type mice infected with L3 stage infectious Nippostrongylus brasiliensis to examine the innate immune response to helminth infection in the lung.

Project description:The goal of this experiment was to examine the innate immune response to helminth infection in the lung. Hookworms (like many other helminths) use an obligate migration pathway through the lung. Their infection has been characterized in the gut in detail, but early immune responses in the lung have not been fully characterized. Experiment Overall Design: SCID mice were used to examine the innate immune response. SCID mice have no functional B or T cells but a fully functional innate immune system. SCID and WT mice were infected with 500 L3 stage infectious Nippostrongylus brasiliensis SC and their lungs were removed at days 2,3,4,8 and 12 post infection.

2007-12-01 | E-GEOD-3414 | biostudies-arrayexpress

miRNA data from extracellular vesicles secreted by Nippostrongylus brasiliensis

Project description:miRNA-Seq analysis of the miRNA present in the extracellular vesicles secreted by the nematode Nippostrongylus brasiliensis

2018-04-01 | GSE111478 | GEO

RNAseq of small intestinal epithelium extracted from mice infected with Nippostrongylus brasiliensis

Project description:The intestinal epithelium is our first line of defense against infections of the gut and the plasticity in cellular differentiation of the intestinal epithelium is an important part of this response. Here we sequenced the small intestinal epithelium from mice infected with Nippostrongylus brasiliensis to determine how the intestinal epithelium adapts in the context of an infection. By comparing these data to small intestinal organoids treated with cytokines (see related accessions) we determine that the intestinal epithelial response to N. brasiliensis infection correspond to a type II infection driven by IL-13.

2022-05-08 | E-MTAB-9183 | biostudies-arrayexpress

Neutrophils promote M2 polarization of macrophages during Nippostrongylus brasiliensis infection

Project description:Microarray profiling of amplified total RNA isolated from neutrophils sorted from naïve, Nippostrongylus brasiliensis (Nb)-infected, or lipopolysaccharide (LPS)-treated mice.

2014-08-30 | GSE46437 | GEO

Expression profiles of innate and Th2 lymphocytes

Project description:We compare the transcription profiles of IL-5-reporter marked ILC2s and Th2 cells sorted from mouse lung tissue after Nippostrongylus brasiliensis infection

2016-10-17 | GSE70020 | GEO

Extracellular vesicles from Nippostrongylus brasiliensis

Project description:We identified the extracellular vesicles (EVs)secreted by the nematode Nippostrongylus brasiliensis. EV proteins were analysed using a 5600+ mass spectrometer (ABSCIEX).

2018-10-19 | PXD009165 | Pride

Human resistin alters lung mRNA expression from helminth-infected lungs.

Project description:Goal: To examine the effects of human resistin during helminth infection. Methodology: To examine the function of human resistin (hResistin), we utilized transgenic mice expressing the human resistin gene along with its entire regulatory region (hRetnTg+). Following infection with the helminth Nippostrongylus brasiliensis, whole lung RNA was sequenced in hRetnTg+ mice, control hRetnTg- and naïve mice. Conclusion: In hRetnTg+ mice, many genes involved in inflammation and the immune system, specifically toll-like receptor signaling and chemokines, are significantly upregulated, suggesting that human resistin promotes TLR signaling and inflammation during helminth infection. Examination of whole lung mRNA from Nippostrongylus brasiliensis-infected lungs at day 7 in mice expressing human resistin

2014-11-14 | E-GEOD-60537 | biostudies-arrayexpress

Genome-Wide Transcriptomic Analysis of Intestinal Tissue to Assess the Impact of Nutrition and a Secondary Nematode Challenge in Lactating Rats

Project description:We use a genome wide transcriptomic approach to assess the effects of protein supplementation on gene expression in the small intestine of periparturient rats during a secondary infection with the rat nematode Nippostrongylus brasiliensis

2011-05-31 | E-TABM-1132 | biostudies-arrayexpress

B cell-intrinsic STAT6 controls the germinal center response in type 2 immunity

Project description:By investigating the germinal center (GC) formation in STAT6ko/WT bone marrow-mixed chimera we found that GC formation in type 2 immune responses is dependent on B cell intrinsic expression of IL-4/IL-13-induced genes. We therefore used microarrays to find Stat6 dependent genes that are important for germinal center formation and/or organization after infection with the nematode Nippostrongylus brasiliensis (N. brasiliensis).

2014-05-26 | GSE47679 | GEO

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