Transcriptomics

Dataset Information

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Stromal-epithelial interaction via soluble factors in prostate carcinoma cell lines


ABSTRACT: Cell-cell communication is an important process in healthy tissue but also gains enhanced attention regarding pathological tissue. To date, the tumor microenvironment is gradually brought into focus when studying tumorigenesis. In the prostate gland, stromal and epithelial cells greatly interact to maintain homeostasis or tissue integrity. This study focuses on an indirect communication via soluble factors. For this approach, the prostate carcinoma cell line LNCaP and the stromal primary cells p21 were co-cultured without direct contact and RNA was isolated at defined time points (one, three and seven days). RNA sequencing finally revealed a time-depending differential expression profile.

ORGANISM(S): Homo sapiens

PROVIDER: GSE210988 | GEO | 2022/08/14

REPOSITORIES: GEO

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