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M6A methylome in JQ1 treatment and control in MDA-MB-231 cells.

ABSTRACT: We report the application of MeRIP sequencing technology for high-throughput profiling of m6A methylome in breast cancer cells. Comparison of m6A methylome between control and BETi-treated cells revealed the following findings: 1) Significant global alteration of methylation sites due to BETi-treatment (herein defined as BETi-m6A signature). 2) Gene Ontology (GO) analysis of the differential meRIP-seq candidates enriched pathways involved in chromatin modification, RNA splicing and pathways regulating cell fate , reflecting a critical role of m6A in diverse biological processes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE219190 | GEO | 2023/12/31

REPOSITORIES: GEO

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